The potential of youth


Previously, I wrote about defying ageing with a focus on miracle creams and lotions. The general consensus is that you cannot stop the ageing process.

However, recently an article popped up in my inbox discussing about how the blood of young mice can rejuvenate older mice. Cue images of horror movies where older people are harvesting young people for their blood!

In reality it is far more complicated than injecting the blood of a young person. We need to know how the young blood factors are acting to ‘rejuvenate’.

The potential of umbilical chord blood

In this particular study the older mice who had received plasma from the umbilical cord blood (UCB) of young mice had more neural connections forming, and showed improved memory and learning compared to control mice.

The researchers found that there was expression of a UCB-specific protein in the hippocampus of the older mice who had received the UCB plasma.

Previously, studies have only been able to demonstrate the ‘rejuvenating’ effects of young blood on older animals through a technique called parabiosis, which is where the circulatory system of two mice are joined (ewww!). Obviously, ethically there would be issues in humans, and in animal research it is a proof-principle technique that is also not overly practical. So knowing that we are able to identify factors in the plasma that can ‘rejuvenate’, is a big win.

UCB can also repair damaged tissue

This same year, another article demonstrated that stem cells isolated from human UCB can prevent kidney failure in rats suffering from acute kidney injury. Currently, human UBC cells are used to treat a range of diseases such as

  • Immune deficiency
  • Leukaemias
  • Blood diseases such as Aplastic and Fanconi Anaemia
  • Metabolic storage diseases
  • Thalassaemia

Final thought

It is undeniable that there are properties of young blood that can ‘defy the ageing process’. In terms of medical research, it seems that these factors will be able to counteract age-related memory loss, and promote repair to damaged organs. Unfortunately, UCB relies on tissues being donated, and has obvious limitations as well as ethical considerations. At the moment these experiments are ‘proof-of-principle’ but pave the way for more UCB-factors to be isolated that may help promote tissue rejuvenation. Think repairing damaged spinal chords!

And, let’s face it, eventually the cosmetic industry will jump on this band wagon to promise ‘age-defying’ treatments!!

Side note

Many hospitals collect human umbilical chord blood. Please consider donating your child’s umbilical chord blood and tissue for medical research or to be used in life-saving treatments.